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PJIE137 carrying blaCTX-M-62 is closely related to p271A carrying blaNDM-1.

ABSTRACT: Complete sequencing of pJIE137 revealed a backbone closely related to p271A, encoding a novel RepA protein but with a similar organization and up to ?70% nucleotide identity to IncN plasmids. A region in pJIE137 resembling the IncN CUP regulon is mostly missing from p271A, presumably due to recombination. The class 1 In/Tn and ISEcp1-bla(CTX-M-62) transposition unit in pJIE137 and a putative transposon carrying bla(NDM-1) in p271A are inserted in different locations in the plasmid backbone.

SUBMITTER: Partridge SR

PROVIDER: S-EPMC3318322 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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pJIE137 carrying blaCTX-M-62 is closely related to p271A carrying blaNDM-1.

Partridge Sally R SR Paulsen Ian T IT Iredell Jonathan R JR

Antimicrobial agents and chemotherapy 20120117 4

Complete sequencing of pJIE137 revealed a backbone closely related to p271A, encoding a novel RepA protein but with a similar organization and up to ∼70% nucleotide identity to IncN plasmids. A region in pJIE137 resembling the IncN CUP regulon is mostly missing from p271A, presumably due to recombination. The class 1 In/Tn and ISEcp1-bla(CTX-M-62) transposition unit in pJIE137 and a putative transposon carrying bla(NDM-1) in p271A are inserted in different locations in the plasmid backbone. ...[more]

PMID: 22252811

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