Population pharmacokinetics of telavancin in healthy subjects and patients with infections.
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ABSTRACT:
SUBMITTER: Samara E
PROVIDER: S-EPMC3318396 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Population pharmacokinetics of telavancin in healthy subjects and patients with infections.
Samara Emil E Shaw Jeng-Pyng JP Barriere Steven L SL Wong Shekman L SL Worboys Philip P
Antimicrobial agents and chemotherapy 20120117 4
A population pharmacokinetic model of telavancin, a lipoglycopeptide antibiotic, was developed and used to identify sources of interindividual variability. Data were obtained from healthy subjects (seven phase 1 studies), patients with complicated skin and skin structure infections (cSSSI; two phase 2 and two phase 3 studies), and patients with hospital-acquired pneumonia (HAP; two phase 3 studies). A two-compartment open model with zero-order input best fit the telavancin data from healthy indi ...[more]
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