The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT.
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ABSTRACT:
SUBMITTER: Sun YC
PROVIDER: S-EPMC3318482 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
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The Yersinia pestis Rcs phosphorelay inhibits biofilm formation by repressing transcription of the diguanylate cyclase gene hmsT.
Sun Yi-Cheng YC Guo Xiao-Peng XP Hinnebusch B Joseph BJ Darby Creg C
Journal of bacteriology 20120210 8
Yersinia pestis, which causes bubonic plague, forms biofilms in fleas, its insect vectors, as a means to enhance transmission. Biofilm development is positively regulated by hmsT, encoding a diguanylate cyclase that synthesizes the bacterial second messenger cyclic-di-GMP. Biofilm development is negatively regulated by the Rcs phosphorelay signal transduction system. In this study, we show that Rcs-negative regulation is accomplished by repressing transcription of hmsT. ...[more]
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