Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells.
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ABSTRACT:
SUBMITTER: Salamon D
PROVIDER: S-EPMC3318621 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Latency type-dependent modulation of Epstein-Barr virus-encoded latent membrane protein 1 expression by type I interferons in B cells.
Salamon Daniel D Adori Monika M Ujvari Dorina D Wu Liang L Kis Lorand L LL Madapura Harsha S HS Nagy Noemi N Klein George G Klein Eva E
Journal of virology 20120215 8
We report that type I interferons (IFNs) upregulate latent membrane protein 1 (LMP-1) expression by direct activation of the ED-L1 promoter in several Epstein-Barr virus (EBV)-carrying Burkitt's lymphoma lines. In EBV-infected primary B cells, IFN-α transiently upregulates LMP-1 mRNA, but not protein levels, followed by downregulation of both, suggesting a novel antiproliferative mechanism of type I IFNs. Furthermore, our results may explain the expression of LMP-1 in memory B cells of systemic ...[more]
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