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Overreliance on the hexon gene, leading to misclassification of human adenoviruses.

ABSTRACT: The genome of human adenovirus (HAdV) D30 was sequenced in depth. Sequence assembly and analysis revealed two distinct viral sequences with identical hexon genes, which were the same as the one previously reported for HAdV-D30. However, one of the two viruses was found to be a recombinant of HAdV-D29. Exclusive reliance on serum neutralization can lead to mischaracterization of adenoviruses and miss coinfections. Whole-genome sequencing remains the gold standard for proper classification of HAdVs.

SUBMITTER: Singh G

PROVIDER: S-EPMC3318657 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Overreliance on the hexon gene, leading to misclassification of human adenoviruses.

Singh Gurdeep G Robinson Christopher M CM Dehghan Shoaleh S Schmidt Timothy T Seto Donald D Jones Morris S MS Dyer David W DW Chodosh James J

Journal of virology 20120201 8

The genome of human adenovirus (HAdV) D30 was sequenced in depth. Sequence assembly and analysis revealed two distinct viral sequences with identical hexon genes, which were the same as the one previously reported for HAdV-D30. However, one of the two viruses was found to be a recombinant of HAdV-D29. Exclusive reliance on serum neutralization can lead to mischaracterization of adenoviruses and miss coinfections. Whole-genome sequencing remains the gold standard for proper classification of HAdV ...[more]

PMID: 22301156

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