Ontology highlight
ABSTRACT:
SUBMITTER: Bothe JR
PROVIDER: S-EPMC3319140 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Bothe Jameson R JR Lowenhaupt Ky K Al-Hashimi Hashim M HM
Journal of the American Chemical Society 20110128 7
Conversion of right-handed B-DNA into left-handed Z-DNA is one of the largest structural transitions in biology that plays fundamental roles in gene expression and regulation. Z-DNA segments must form within genomes surrounded by a sea of B-DNA and require creation of energetically costly B/Z junctions. Here, we show using a combination of natural abundance NMR R(1ρ) carbon relaxation measurements and CD spectroscopy that sequence-specific B-DNA flexibility modulates the thermodynamic propensity ...[more]