Molecular origins of DNA flexibility: sequence effects on conformational and mechanical properties.
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ABSTRACT:
SUBMITTER: Ortiz V
PROVIDER: S-EPMC3410732 | biostudies-literature | 2011 Jun
REPOSITORIES: biostudies-literature
Publications
Molecular origins of DNA flexibility: sequence effects on conformational and mechanical properties.
Ortiz Vanessa V de Pablo Juan J JJ
Physical review letters 20110610 23
A central question in biophysics is whether DNA sequence affects its mechanical properties, which are thought to influence nucleosome positioning and gene expression. Previous attempts to answer this question have been hindered by an inability to resolve DNA structure and dynamics at the base-pair level. Here we use a model to measure the effects of sequence on the stability of DNA under bending. Sequence is shown to influence DNA's flexibility and its ability to form kinks, which arise when cer ...[more]
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