Ontology highlight
ABSTRACT:
SUBMITTER: Sekiguchi H
PROVIDER: S-EPMC3319330 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Sekiguchi Haruki H Ii Masaaki M Jujo Kentaro K Renault Marie-Ange MA Thorne Tina T Clarke Trevor T Ito Aiko A Tanaka Toshikazu T Klyachko Ekaterina E Tabata Yasuhiko Y Hagiwara Nobuhisa N Losordo Douglas D
Laboratory investigation; a journal of technical methods and pathology 20120213 4
Both estradiol (E2) and Sonic Hedgehog (Shh) contribute to angiogenesis and nerve regeneration. Here, we investigated whether E2 improves the recovery of injured nerves by downregulating the Shh inhibitor hedgehog-interacting protein (HIP) and increasing Shh-induced angiogenesis. Mice were treated with local injections of E2 or placebo one week before nerve-crush injury; 28 days after injury, nerve conduction velocity, exercise duration, and vascularity were significantly greater in E2-treated m ...[more]