Ontology highlight
ABSTRACT:
SUBMITTER: Sekiguchi H
PROVIDER: S-EPMC3806485 | biostudies-literature | 2013 Jan
REPOSITORIES: biostudies-literature
Sekiguchi Haruki H Ii Masaaki M Jujo Kentaro K Thorne Tina T Ito Aiko A Klyachko Ekaterina E Hamada Hiromichi H Kessler John A JA Tabata Yasuhiko Y Kawana Masatoshi M Asahi Michio M Hagiwara Nobuhisa N Losordo Douglas W DW
Angiogenesis 20120902 1
Neural stem cells (NSCs) differentiate into endothelial cells (ECs) and neuronal cells. Estradiol (E2) is known to exhibit proangiogenic effects on ischemic tissues via EC activation. Therefore, we hypothesized that E2 can promote the therapeutic potential of NSC transplantation for injured nerve repair via the differentiation of NSCs into ECs during neovascularization. NSCs isolated from newborn mouse brains were transplanted into injured sciatic nerves with (NSC/E2 group) or without E2-conjuga ...[more]