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Synthesis of chromans via Pd-catalyzed alkene carboetherification reactions.

ABSTRACT: A new method for the construction of 2-substituted and 2,2-disubstituted chromans via Pd-catalyzed carboetherification reactions between aryl/alkenyl halides and 2-(but-3-en-1-yl)phenols is described. These reactions effect formation of a C-O bond and a C-C bond to afford the chroman products in good yield, and also provide stereoselective access to tricyclic chroman derivatives.

SUBMITTER: Ward AF

PROVIDER: S-EPMC3319722 | biostudies-literature | 2012 Jan

REPOSITORIES: biostudies-literature

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Synthesis of chromans via Pd-catalyzed alkene carboetherification reactions.

Ward Amanda F AF Xu Yan Y Wolfe John P JP

Chemical communications (Cambridge, England) 20111124 4

A new method for the construction of 2-substituted and 2,2-disubstituted chromans via Pd-catalyzed carboetherification reactions between aryl/alkenyl halides and 2-(but-3-en-1-yl)phenols is described. These reactions effect formation of a C-O bond and a C-C bond to afford the chroman products in good yield, and also provide stereoselective access to tricyclic chroman derivatives. ...[more]

PMID: 22113305

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