Ontology highlight
ABSTRACT:
SUBMITTER: Yu JX
PROVIDER: S-EPMC3320041 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Yu Jian-Xin JX Kodibagkar Vikram D VD Hallac Rami R RR Liu Li L Mason Ralph P RP
Bioconjugate chemistry 20120301 3
Increased emphasis on personalized medicine and novel therapies requires the development of noninvasive strategies for assessing biochemistry in vivo. The detection of enzyme activity and gene expression in vivo is potentially important for the characterization of diseases and gene therapy. Magnetic resonance imaging (MRI) is a particularly promising tool, since it is noninvasive and has no associated radioactivity, yet penetrates deep tissue. We now demonstrate a novel class of dual (1)H/(19)F ...[more]