Ontology highlight
ABSTRACT:
SUBMITTER: Lilley LM
PROVIDER: S-EPMC6923588 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Lilley Laura M LM Kamper Sarah S Caldwell Michael M Chia Zer Keen ZK Ballweg David D Vistain Luke L Krimmel Jeffrey J Mills Teresa Anne TA MacRenaris Keith K Lee Paul P Waters Emily Alexandria EA Meade Thomas J TJ
Angewandte Chemie (International ed. in English) 20191121 1
Our lab has developed a new series of self-immolative MR agents for the rapid detection of enzyme activity in mouse models expressing β-galactosidase (β-gal). We investigated two molecular architectures to create agents that detect β-gal activity by modulating the coordination of water to Gd<sup>III</sup> . The first is an intermolecular approach, wherein we designed several structural isomers to maximize coordination of endogenous carbonate ions. The second involves an intramolecular mechanism ...[more]