Ontology highlight
ABSTRACT:
SUBMITTER: Ghochani Y
PROVIDER: S-EPMC3320250 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Ghochani Yasmin Y Saini Jasjit K JK Mellon Pamela L PL Thackray Varykina G VG
Endocrinology 20120131 4
Differential regulation of gonadotropin hormone production in the pituitary is critical for fertility. Activin and progesterone signaling in gonadotrope cells is important for Fshb gene expression. Previously, we reported that synergy between activin and progestins required the binding of SMAD proteins and the progesterone receptor (PR) to the murine Fshb promoter. In this study, we demonstrate that the FOXL2 transcription factor is also necessary for the full synergistic response between activi ...[more]