Ontology highlight
ABSTRACT:
SUBMITTER: Fortin J
PROVIDER: S-EPMC4101660 | biostudies-literature | 2014 Aug
REPOSITORIES: biostudies-literature
Fortin Jérôme J Boehm Ulrich U Deng Chu-Xia CX Treier Mathias M Bernard Daniel J DJ
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 20140416 8
Follicle-stimulating hormone (FSH) is an essential regulator of gonadal function and fertility. Loss-of-function mutations in the FSHB/Fshb gene cause hypogonadotropic hypogonadism in humans and mice. Both gonadotropin-releasing hormone (GnRH) and activins, members of the transforming growth factor β (TGFβ) superfamily, stimulate FSH synthesis; yet, their relative roles and mechanisms of action in vivo are unknown. Here, using conditional gene-targeting, we show that the canonical mediator of TG ...[more]