Ontology highlight
ABSTRACT:
SUBMITTER: Li Q
PROVIDER: S-EPMC3320855 | biostudies-literature | 2011 Feb
REPOSITORIES: biostudies-literature
Li Quanxi Q Kannan Athilakshmi A DeMayo Francesco J FJ Lydon John P JP Cooke Paul S PS Yamagishi Hiroyuki H Srivastava Deepak D Bagchi Milan K MK Bagchi Indrani C IC
Science (New York, N.Y.) 20110201 6019
During pregnancy, progesterone inhibits the growth-promoting actions of estrogen in the uterus. However, the mechanism for this is not clear. The attenuation of estrogen-mediated proliferation of the uterine epithelium by progesterone is a prerequisite for successful implantation. Our study reveals that progesterone-induced expression of the basic helix-loop-helix transcription factor Hand2 in the uterine stroma suppresses the production of several fibroblast growth factors (FGFs) that act as pa ...[more]