Ontology highlight
ABSTRACT:
SUBMITTER: Hill DA
PROVIDER: S-EPMC3321082 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Hill David A DA Siracusa Mark C MC Abt Michael C MC Kim Brian S BS Kobuley Dmytro D Kubo Masato M Kambayashi Taku T Larosa David F DF Renner Ellen D ED Orange Jordan S JS Bushman Frederic D FD Artis David D
Nature medicine 20120325 4
Commensal bacteria that colonize mammalian barrier surfaces are reported to influence T helper type 2 (T(H)2) cytokine-dependent inflammation and susceptibility to allergic disease, although the mechanisms that underlie these observations are poorly understood. In this report, we find that deliberate alteration of commensal bacterial populations via oral antibiotic treatment resulted in elevated serum IgE concentrations, increased steady-state circulating basophil populations and exaggerated bas ...[more]