Ontology highlight
ABSTRACT:
SUBMITTER: Okamoto K
PROVIDER: S-EPMC3321205 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Okamoto Koji K Ishiguro Tatsuya T Midorikawa Yutaka Y Ohata Hirokazu H Izumiya Masashi M Tsuchiya Naoto N Sato Ai A Sakai Hiroaki H Nakagama Hitoshi H
The EMBO journal 20120228 7
Liver metastasis is a major lethal complication associated with colon cancer, and post-intravasation steps of the metastasis are important for its clinical intervention. In order to identify inhibitory microRNAs (miRNAs) for these steps, we performed 'dropout' screens of a miRNA library in a mouse model of liver metastasis. Functional analyses showed that miR-493 and to a lesser extent miR-493(*) were capable of inhibiting liver metastasis. miR-493 inhibited retention of metastasized cells in li ...[more]