Ontology highlight
ABSTRACT:
SUBMITTER: Cho JH
PROVIDER: S-EPMC3321625 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Cho J-H JH Lee M-K MK Yoon K W KW Lee J J Cho S-G SG Choi E-J EJ
Cell death and differentiation 20111118 5
Protein arginine methylation, catalyzed by protein arginine methyltransferases (PRMTs), is implicated in modulation of cellular processes including gene transcription. The role of PRMTs in the regulation of intracellular signaling pathways has remained obscure, however. We now show that PRMT1 methylates apoptosis signal-regulating kinase 1 (ASK1) at arginine residues 78 and 80 and thereby negatively regulates ASK1 signaling. PRMT1-mediated ASK1 methylation attenuated the H(2)O(2)-induced stimula ...[more]