Ontology highlight
ABSTRACT:
SUBMITTER: Huang C
PROVIDER: S-EPMC7205891 | biostudies-literature | 2020 Jan
REPOSITORIES: biostudies-literature
Huang Chuyu C Chen Yan Y Dai Huaiqian H Zhang Huan H Xie Minyu M Zhang Hanbin H Chen Feilong F Kang Xiangjin X Bai Xiaochun X Chen Zhenguo Z
Cell death and differentiation 20190521 1
Stress granules (SGs) are discrete assemblies of stalled messenger ribonucleoprotein complexes (mRNPs) that form when eukaryotic cells encounter environmental stress. RNA-binding proteins (RBPs) mediate their condensation by recruiting populations of mRNPs. However, the cellular and molecular mechanisms underlying the role of ubiquitin-associated protein 2-like (UBAP2L) in the regulation of SG dynamics remain elusive. Here, we show that UBAP2L is required for both SG assembly and disassembly. UB ...[more]