Ontology highlight
ABSTRACT:
SUBMITTER: Tumanov AV
PROVIDER: S-EPMC3321833 | biostudies-literature | 2010 Nov
REPOSITORIES: biostudies-literature
Tumanov Alexei V AV Grivennikov Sergei I SI Kruglov Andrei A AA Shebzukhov Yuriy V YV Koroleva Ekaterina P EP Piao Yulan Y Cui Chang-Yi CY Kuprash Dmitry V DV Nedospasov Sergei A SA
Blood 20100715 18
Secondary lymphoid organs provide a unique microenvironment for generation of immune responses. Using a cell type-specific conditional knockout approach, we have dissected contributions of tumor necrosis factor (TNF) produced by B cells (B-TNF) or T cells (T-TNF) to the genesis and homeostatic organization of secondary lymphoid organs. In spleen, lymph nodes and Peyer patches, the cellular source of TNF, and its molecular form (soluble versus membrane-bound) appeared distinct. In spleen, in addi ...[more]