Ontology highlight
ABSTRACT:
SUBMITTER: Gelman AE
PROVIDER: S-EPMC3760174 | biostudies-literature | 2009 Apr
REPOSITORIES: biostudies-literature
Journal of immunology (Baltimore, Md. : 1950) 20090401 7
It is the prevailing view that adaptive immune responses are initiated in secondary lymphoid organs. Studies using alymphoplastic mice have shown that secondary lymphoid organs are essential to initiate allograft rejection of skin, heart, and small bowel. The high immunogenicity of lungs is well recognized and allograft rejection remains a major contributing factor to poor outcomes after lung transplantation. We show in this study that alloreactive T cells are initially primed within lung allogr ...[more]