Fast gapped-read alignment with Bowtie 2.
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ABSTRACT:
SUBMITTER: Langmead B
PROVIDER: S-EPMC3322381 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Publications
Fast gapped-read alignment with Bowtie 2.
Langmead Ben B Salzberg Steven L SL
Nature methods 20120304 4
As the rate of sequencing increases, greater throughput is demanded from read aligners. The full-text minute index is often used to make alignment very fast and memory-efficient, but the approach is ill-suited to finding longer, gapped alignments. Bowtie 2 combines the strengths of the full-text minute index with the flexibility and speed of hardware-accelerated dynamic programming algorithms to achieve a combination of high speed, sensitivity and accuracy. ...[more]
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