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Staphylococcus aureus biofilms: properties, regulation, and roles in human disease.


ABSTRACT: Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies.

SUBMITTER: Archer NK 

PROVIDER: S-EPMC3322633 | biostudies-literature | 2011 Sep-Oct

REPOSITORIES: biostudies-literature

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Staphylococcus aureus biofilms: properties, regulation, and roles in human disease.

Archer Nathan K NK   Mazaitis Mark J MJ   Costerton J William JW   Leid Jeff G JG   Powers Mary Elizabeth ME   Shirtliff Mark E ME  

Virulence 20110901 5


Increasing attention has been focused on understanding bacterial biofilms and this growth modality's relation to human disease. In this review we explore the genetic regulation and molecular components involved in biofilm formation and maturation in the context of the Gram-positive cocci, Staphylococcus aureus. In addition, we discuss diseases and host immune responses, along with current therapies associated with S. aureus biofilm infections and prevention strategies. ...[more]

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