Ontology highlight
ABSTRACT:
SUBMITTER: Brain E
PROVIDER: S-EPMC3322949 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Brain E E Isambert N N Dalenc F F Diéras V V Bonneterre J J Rezai K K Jimenez M M Mefti-Lacheraf F F Cottura E E Tresca P P Vanlemmens L L Mahier-Aït Oukhatar C C Lokiec F F Fumoleau P P
British journal of cancer 20120112 4
<h4>Background</h4>To determine the recommended doses of lapatinib (LPT) combined with vinorelbine (VNR) in women with human epidermal growth factor receptor 2-overexpressing advanced breast cancer pretreated with trastuzumab.<h4>Methods</h4>In this phase I study, women were treated with oral daily LPT and i.v. VNR infused on days 1 and 8 every 3 weeks. Dose levels (DL) of LPT (mg)/VNR (mg m(-2)) ranged from 750/20 to 1250/30. The primary end point was feasibility based on maximal tolerated dose ...[more]