Ontology highlight
ABSTRACT:
SUBMITTER: Boehringer D
PROVIDER: S-EPMC3323044 | biostudies-literature | 2012 Mar
REPOSITORIES: biostudies-literature
Boehringer Daniel D O'Farrell Heather C HC Rife Jason P JP Ban Nenad N
The Journal of biological chemistry 20120203 13
The assembly of the ribosomal subunits is facilitated by ribosome biogenesis factors. The universally conserved methyltransferase KsgA modifies two adjacent adenosine residues in the 3'-terminal helix 45 of the 16 S ribosomal RNA (rRNA). KsgA recognizes its substrate adenosine residues only in the context of a near mature 30S subunit and is required for the efficient processing of the rRNA termini during ribosome biogenesis. Here, we present the cryo-EM structure of KsgA bound to a nonmethylated ...[more]