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Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.

ABSTRACT: Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants.To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise.We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or pedaling a cycle ergometer for 30 minutes every hour over 4 hours in a climate-controlled chamber with a target ventilation of 20 L/min/m2 body surface area.Intermittent moderate-intensity exercise induced a systemic proinflammatory response characterized by increases in leukocyte counts, C-reactive protein, monocyte chemoattractant protein-1, and interleukin-6, but did not change coagulation tendency or heart rate variability.Interpretation of pollutant-induced inflammatory responses in inhalational exposure studies should account for signals and noises caused by exercise, especially when the effect size is small.

SUBMITTER: Donde A

PROVIDER: S-EPMC3323713 | biostudies-literature | 2012 Apr

REPOSITORIES: biostudies-literature

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Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.

Donde Aneesh A Wong Hofer H Frelinger Jessica J Power Karron K Balmes John R JR Arjomandi Mehrdad M

Journal of occupational and environmental medicine 20120401 4

<h4>Background</h4>Intermittent moderate-intensity exercise is used in human inhalational exposure studies to increase the effective dose of air pollutants.<h4>Objective</h4>To investigate the inflammatory, coagulatory, and autonomic effects of intermittent moderate-intensity exercise.<h4>Methods</h4>We measured hemodynamic, electrocardiographic, inflammatory, and coagulatory parameters in peripheral blood of 25 healthy subjects across an exercise protocol that included running on a treadmill or ...[more]

PMID: 22418276

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Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.

Publications

Effects of exercise on systemic inflammatory, coagulatory, and cardiac autonomic parameters in an inhalational exposure study.

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