Ontology highlight
ABSTRACT:
SUBMITTER: Chen W
PROVIDER: S-EPMC3324294 | biostudies-literature | 2010 Jul
REPOSITORIES: biostudies-literature
Chen Wen W Dailey Harry A HA Paw Barry H BH
Blood 20100428 4
In erythroid cells, ferrous iron is imported into the mitochondrion by mitoferrin-1 (Mfrn1). Previously, we showed that Mfrn1 interacts with Abcb10 to enhance mitochondrial iron importation. Herein we have derived stable Friend mouse erythroleukemia (MEL) cell clones expressing either Mfrn1-FLAG or Abcb10-FLAG and by affinity purification and mass spectrometry have identified ferrochelatase (Fech) as an interacting protein for both Mfrn1 and Abcb10. Fech is the terminal heme synthesis enzyme to ...[more]