Ontology highlight
ABSTRACT:
SUBMITTER: Hsiung PL
PROVIDER: S-EPMC3324975 | biostudies-literature | 2008 Apr
REPOSITORIES: biostudies-literature
Hsiung Pei-Lin PL Hardy Jonathan J Friedland Shai S Soetikno Roy R Du Christine B CB Wu Amy P AP Sahbaie Peyman P Crawford James M JM Lowe Anson W AW Contag Christopher H CH Wang Thomas D TD
Nature medicine 20080316 4
A combination of targeted probes and new imaging technologies provides a powerful set of tools with the potential to improve the early detection of cancer. To develop a probe for detecting colon cancer, we screened phage display peptide libraries against fresh human colonic adenomas for high-affinity ligands with preferential binding to premalignant tissue. We identified a specific heptapeptide sequence, VRPMPLQ, which we synthesized, conjugated with fluorescein and tested in patients undergoing ...[more]