Ontology highlight
ABSTRACT:
SUBMITTER: Jung JC
PROVIDER: S-EPMC2826362 | biostudies-literature | 2004 Nov
REPOSITORIES: biostudies-literature
Jung Juergen C JC Mehta Amit D AD Aksay Emre E Stepnoski Raymond R Schnitzer Mark J MJ
Journal of neurophysiology 20040505 5
One of the major limitations in the current set of techniques available to neuroscientists is a dearth of methods for imaging individual cells deep within the brains of live animals. To overcome this limitation, we developed two forms of minimally invasive fluorescence microendoscopy and tested their abilities to image cells in vivo. Both one- and two-photon fluorescence microendoscopy are based on compound gradient refractive index (GRIN) lenses that are 350-1,000 microm in diameter and provide ...[more]