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AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.


ABSTRACT: Axon-dendrite polarization is crucial for neural network wiring and information processing in the brain. Polarization begins with the transformation of a single neurite into an axon and its subsequent rapid extension, which requires coordination of cellular energy status to allow for transport of building materials to support axon growth. We found that activation of the energy-sensing adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway suppressed axon initiation and neuronal polarization. Phosphorylation of the kinesin light chain of the Kif5 motor protein by AMPK disrupted the association of the motor with phosphatidylinositol 3-kinase (PI3K), preventing PI3K targeting to the axonal tip and inhibiting polarization and axon growth.

SUBMITTER: Amato S 

PROVIDER: S-EPMC3325765 | biostudies-literature | 2011 Apr

REPOSITORIES: biostudies-literature

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AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.

Amato Stephen S   Liu Xiuxin X   Zheng Bin B   Cantley Lewis L   Rakic Pasko P   Man Heng-Ye HY  

Science (New York, N.Y.) 20110324 6026


Axon-dendrite polarization is crucial for neural network wiring and information processing in the brain. Polarization begins with the transformation of a single neurite into an axon and its subsequent rapid extension, which requires coordination of cellular energy status to allow for transport of building materials to support axon growth. We found that activation of the energy-sensing adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway suppressed axon initiation and neuronal  ...[more]

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