AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.
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ABSTRACT:
SUBMITTER: Amato S
PROVIDER: S-EPMC3325765 | biostudies-literature | 2011 Apr
REPOSITORIES: biostudies-literature
Publications
AMP-activated protein kinase regulates neuronal polarization by interfering with PI 3-kinase localization.
Amato Stephen S Liu Xiuxin X Zheng Bin B Cantley Lewis L Rakic Pasko P Man Heng-Ye HY
Science (New York, N.Y.) 20110324 6026
Axon-dendrite polarization is crucial for neural network wiring and information processing in the brain. Polarization begins with the transformation of a single neurite into an axon and its subsequent rapid extension, which requires coordination of cellular energy status to allow for transport of building materials to support axon growth. We found that activation of the energy-sensing adenosine 5'-monophosphate (AMP)-activated protein kinase (AMPK) pathway suppressed axon initiation and neuronal ...[more]
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