Ontology highlight
ABSTRACT:
SUBMITTER: Chen DY
PROVIDER: S-EPMC3325786 | biostudies-literature | 2012 Feb
REPOSITORIES: biostudies-literature
Chen David Y DY Lee Yishan Y Van Tine Brian A BA Searleman Adam C AC Westergard Todd D TD Liu Han H Tu Ho-Chou HC Takeda Shugaku S Dong Yiyu Y Piwnica-Worms David R DR Oh Kyoung J KJ Korsmeyer Stanley J SJ Hermone Ann A Gussio Richard R Shoemaker Robert H RH Cheng Emily H-Y EH Hsieh James J-D JJ
Cancer research 20111213 3
The threonine endopeptidase Taspase1 has a critical role in cancer cell proliferation and apoptosis. In this study, we developed and evaluated small molecule inhibitors of Taspase1 as a new candidate class of therapeutic modalities. Genetic deletion of Taspase1 in the mouse produced no overt deficiencies, suggesting the possibility of a wide therapeutic index for use of Taspase1 inhibitors in cancers. We defined the peptidyl motifs recognized by Taspase1 and conducted a cell-based dual-fluoresce ...[more]