Ontology highlight
ABSTRACT:
SUBMITTER: Grantz Saskova K
PROVIDER: S-EPMC3957959 | biostudies-literature | 2014 Mar
REPOSITORIES: biostudies-literature
Grantz Šašková Klára K Kozíšek Milan M Stray Kirsten K de Jong Dorien D Rezáová Pavlína P Brynda Jirí J van Maarseveen Noortje M NM Nijhuis Monique M Cihlár Tomáš T Konvalinka Jan J
Journal of virology 20131226 6
Insertions in the protease (PR) region of human immunodeficiency virus (HIV) represent an interesting mechanism of antiviral resistance against HIV PR inhibitors (PIs). Here, we demonstrate the improved ability of a phosphonate-containing experimental HIV PI, GS-8374, relative to that of other PIs, to effectively inhibit patient-derived recombinant HIV strains bearing PR insertions and numerous other mutations. We correlate enzyme inhibition with the catalytic activities of corresponding recombi ...[more]