Ontology highlight
ABSTRACT:
SUBMITTER: Blackwood JK
PROVIDER: S-EPMC3326311 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Nucleic acids research 20111201 7
Helicase-nuclease systems dedicated to DNA end resection in preparation for homologous recombination (HR) are present in all kingdoms of life. In thermophilic archaea, the HerA helicase and NurA nuclease cooperate with the highly conserved Mre11 and Rad50 proteins during HR-dependent DNA repair. Here we show that HerA and NurA must interact in a complex with specific subunit stoichiometry to process DNA ends efficiently. We determine crystallographically that NurA folds in a toroidal dimer of in ...[more]