Combinatorial biosynthesis of polyketides--a perspective.
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ABSTRACT:
SUBMITTER: Wong FT
PROVIDER: S-EPMC3328608 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
Combinatorial biosynthesis of polyketides--a perspective.
Wong Fong T FT Khosla Chaitan C
Current opinion in chemical biology 20120216 1-2
Since their discovery, polyketide synthases have been attractive targets of biosynthetic engineering to make 'unnatural' natural products. Although combinatorial biosynthesis has made encouraging advances over the past two decades, the field remains in its infancy. In this enzyme-centric perspective, we discuss the scientific and technological challenges that could accelerate the adoption of combinatorial biosynthesis as a method of choice for the preparation of encoded libraries of bioactive sm ...[more]
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