Ontology highlight
ABSTRACT:
SUBMITTER: Torres JP
PROVIDER: S-EPMC7280274 | biostudies-literature | 2020 Jun
REPOSITORIES: biostudies-literature
Nature communications 20200608 1
Complex polyketides are typically associated with microbial metabolism. Here, we report that animals also make complex, microbe-like polyketides. We show there is a widespread branch of fatty acid synthase- (FAS)-like polyketide synthase (PKS) proteins, which sacoglossan animals use to synthesize complex products. The purified sacogolassan protein EcPKS1 uses only methylmalonyl-CoA as a substrate, otherwise unknown in animal lipid metabolism. Sacoglossans are sea slugs, some of which eat algae, ...[more]