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Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.

ABSTRACT: Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-? in the induced THP-1 (pro-monocytic leukemia cell line) assay.

SUBMITTER: Stierle DB

PROVIDER: S-EPMC3330828 | biostudies-literature | 2012 Feb

REPOSITORIES: biostudies-literature

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Caspase-1 and -3 inhibiting drimane sesquiterpenoids from the extremophilic fungus Penicillium solitum.

Stierle Donald B DB Stierle Andrea A AA Girtsman Teri T McIntyre Kyle K Nichols Jesse J

Journal of natural products 20120125 2

Two new drimane sesquiterpene lactones and one new tricarboxylic acid derivative were isolated from the Berkeley Pit extremophilic fungus Penicillium solitum. The structures of these compounds were deduced by spectroscopic analysis. Berkedrimanes A and B inhibited the signal transduction enzymes caspase-1 and caspase-3 and mitigated the production of interleukin 1-β in the induced THP-1 (pro-monocytic leukemia cell line) assay. ...[more]

PMID: 22276851

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