Predicting responses to sunitinib using single nucleotide polymorphisms: Progress and recommendations for future trials.
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ABSTRACT:
SUBMITTER: Ganapathi RN
PROVIDER: S-EPMC3334544 | biostudies-literature | 2011
REPOSITORIES: biostudies-literature
Publications
Predicting responses to sunitinib using single nucleotide polymorphisms: Progress and recommendations for future trials.
Ganapathi Ram N RN Bukowski Ronald M RM
Genome medicine 20111230 12
Targeted therapy with tyrosine kinase inhibitors has led to a substantial improvement in the standard of care for patients with advanced or metastatic clear cell renal cell carcinoma. Because the mechanism of action, metabolism and transport of tyrosine kinase inhibitors can affect outcome and toxicity, several investigators have pursued the identification of single nucleotide polymorphisms (SNPs) in genes associated with these actions. We discuss SNPs associated with outcome and toxicity follow ...[more]
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