Ontology highlight
ABSTRACT:
SUBMITTER: Santner T
PROVIDER: S-EPMC3334826 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Santner Tobias T Siegmund Vanessa V Marx Andreas A Micura Ronald R
Bioorganic & medicinal chemistry 20120204 7
Modified nucleoside triphosphates (NTPs) represent powerful building blocks to generate nucleic acids with novel properties by enzymatic synthesis. We have recently demonstrated the access to 2'-SeCH(3)-uridine and 2'-SeCH(3)-cytidine derivatized RNAs for applications in RNA crystallography, using the corresponding nucleoside triphosphates and distinct mutants of T7 RNA polymerase. In the present note, we introduce the chemical synthesis of the novel 2'-methylseleno-2'-deoxyadenosine and -guanos ...[more]