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Synthesis of 6-Se-guanosine RNAs for structural study.


ABSTRACT: 6-Se-guanosine phosphoramidite and RNAs have been synthesized by selenium substitution of the 6-oxygen atom, and it is revealed that the Se-derivatization is relatively stable and that bulge and wobble structures can better accommodate a large Se atom than a duplex. This Se-modification is useful in the structural study of RNAs and their protein complexes.

SUBMITTER: Salon J 

PROVIDER: S-EPMC3763942 | biostudies-literature | 2013 Aug

REPOSITORIES: biostudies-literature

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Synthesis of 6-Se-guanosine RNAs for structural study.

Salon Jozef J   Gan Jianhua J   Abdur Rob R   Liu Hehua H   Huang Zhen Z  

Organic letters 20130716 15


6-Se-guanosine phosphoramidite and RNAs have been synthesized by selenium substitution of the 6-oxygen atom, and it is revealed that the Se-derivatization is relatively stable and that bulge and wobble structures can better accommodate a large Se atom than a duplex. This Se-modification is useful in the structural study of RNAs and their protein complexes. ...[more]

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