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Targeting angiogenesis in gynecologic cancers.

ABSTRACT: Gynecologic malignancies carry an estimated incidence of 83,750 cases per year and estimated mortality rate of more than 27,000 women per year. New therapies and therapeutic approaches are needed to improve the outlook for women with gynecologic cancers. Recent insights at the molecular and cellular levels are paving the way for a more directed approach to target mechanisms driving tumorigenesis. This article reviews the roles of new and emerging antiangiogenesis drugs, summarizes the data obtained from clinical trials of antiangiogenic agents, and discusses trials under way to address the role of such strategies in gynecologic cancers.

SUBMITTER: Zand B

PROVIDER: S-EPMC3334841 | biostudies-literature | 2012 Jun

REPOSITORIES: biostudies-literature

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Targeting angiogenesis in gynecologic cancers.

Zand Behrouz B Coleman Robert L RL Sood Anil K AK

Hematology/oncology clinics of North America 20120601 3

Gynecologic malignancies carry an estimated incidence of 83,750 cases per year and estimated mortality rate of more than 27,000 women per year. New therapies and therapeutic approaches are needed to improve the outlook for women with gynecologic cancers. Recent insights at the molecular and cellular levels are paving the way for a more directed approach to target mechanisms driving tumorigenesis. This article reviews the roles of new and emerging antiangiogenesis drugs, summarizes the data obtai ...[more]

PMID: 22520979

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