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HOTAIR: a key regulator in gynecologic cancers.

ABSTRACT: Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. HOTAIR promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and signaling pathways. HOTAIR is deregulated in many human cancers; despite its critical roles in health and disease, the underlying mechanisms governing HOTAIR function are unknown. In this review, we summarize the recent findings on the roles of HOTAIR in gynecologic cancers.

SUBMITTER: Li J

PROVIDER: S-EPMC5480152 | biostudies-other | 2017

REPOSITORIES: biostudies-other

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HOTAIR: a key regulator in gynecologic cancers.

Li Jing J Wang Jing J Zhong Yan Y Guo Ruixia R Chu Danxia D Qiu Haifeng H Yuan Zhongfu Z

Cancer cell international 20170621

Long non-coding RNAs (lncRNAs) play critical roles in the initiation and progression of human cancers. HOX transcript antisense RNA (HOTAIR) is an lncRNA localized to the mammalian HOXC gene cluster; it can interact with polycomb repressive complex 2 and the lysine-specific histone demethylase/CoREST/REST complex, and it manipulates the expression of various genes. HOTAIR promotes tumor invasion and metastasis by silencing tumor suppressors, and activating oncogenes and sign ...[more]

PMID: 28649178

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