C. elegans detects pathogen-induced translational inhibition to activate immune signaling.
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ABSTRACT:
SUBMITTER: Dunbar TL
PROVIDER: S-EPMC3334869 | biostudies-literature | 2012 Apr
REPOSITORIES: biostudies-literature
Publications
C. elegans detects pathogen-induced translational inhibition to activate immune signaling.
Dunbar Tiffany L TL Yan Zhi Z Balla Keir M KM Smelkinson Margery G MG Troemel Emily R ER
Cell host & microbe 20120401 4
Pathogens commonly disrupt host cell processes or cause damage, but the surveillance mechanisms used by animals to monitor these attacks are poorly understood. Upon infection with pathogenic Pseudomonas aeruginosa, the nematode C. elegans upregulates infection response gene irg-1 using the zip-2 bZIP transcription factor. Here we show that P. aeruginosa infection inhibits mRNA translation in the intestine via the endocytosed translation inhibitor Exotoxin A, which leads to an increase in ZIP-2 p ...[more]
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