Ontology highlight
ABSTRACT:
SUBMITTER: Chen AT
PROVIDER: S-EPMC3334890 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Chen Alex T AT Cornberg Markus M Gras Stephanie S Guillonneau Carole C Rossjohn Jamie J Trees Andrew A Emonet Sebastien S de la Torre Juan C JC Welsh Raymond M RM Selin Liisa K LK
PLoS pathogens 20120419 4
T cell cross-reactivity between different strains of the same virus, between different members of the same virus group, and even between unrelated viruses is a common occurrence. We questioned here how an intervening infection with a virus containing a sub-dominant cross-reactive T cell epitope would affect protective immunity to a previously encountered virus. Pichinde virus (PV) and lymphocytic choriomeningitis virus (LCMV) encode subdominant cross-reactive NP₂₀₅₋₂₁₂ CD8 T cell epitopes sharin ...[more]