Ontology highlight
ABSTRACT:
SUBMITTER: Westesson O
PROVIDER: S-EPMC3335033 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Westesson Oscar O Lunter Gerton G Paten Benedict B Holmes Ian I
PloS one 20120420 4
The Multiple Sequence Alignment (MSA) is a computational abstraction that represents a partial summary either of indel history, or of structural similarity. Taking the former view (indel history), it is possible to use formal automata theory to generalize the phylogenetic likelihood framework for finite substitution models (Dayhoff's probability matrices and Felsenstein's pruning algorithm) to arbitrary-length sequences. In this paper, we report results of a simulation-based benchmark of several ...[more]