Ontology highlight
ABSTRACT:
SUBMITTER: Farhana L
PROVIDER: S-EPMC3335256 | biostudies-literature | 2012
REPOSITORIES: biostudies-literature
Farhana Lulu L Dawson Marcia I MI Das Jayanta K JK Murshed Farhan F Xia Zebin Z Hadden Timothy J TJ Hatfield James J Fontana Joseph A JA
Journal of oncology 20120405
Pancreatic carcinoma has a dismal prognosis as it often presents as locally advanced or metastatic. We have found that exposure to adamantyl-substituted retinoid-related (ARR) compounds 3-Cl-AHPC and AHP3 resulted in growth inhibition and apoptosis induction in PANC-1, Capan-2, and MiaPaCa-2 pancreatic cancer cell lines. In addition, AHP3 and 3-Cl-AHPC inhibited growth and induced apoptosis in spheres derived from the CD44(+)/CD24(+) (CD133(+)/EpCAM(+)) stem-like cell population isolated from th ...[more]