Dataset Information

Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study.

ABSTRACT:

Background

understanding the determinants of health burden after a fracture in ageing populations is important.

Objective

assess the effect of clinical vertebral and other osteoporotic fractures on function and the subsequent risk of hospitalisation.

Design

individuals from the prospective population-based cohort study Age, Gene/Environment Susceptibility (AGES)-Reykjavik study were examined between 2002 and 2006 and followed up for 5.4 years.

Subjects

a total of 5,764 individuals, 57.7% women, born 1907-35, mean age 77.

Method

four groups with a verified fracture status were used; vertebral fractures, other osteoporotic fractures excluding vertebral, non-osteoporotic fractures and not-fractured were compared and analysed for the effect on mobility, strength, QoL, ADL, co-morbidity and hospitalisation.

Results

worst performance on functional tests was in the vertebral fracture group for women (P < 0.0001) and the other osteoporotic fractures group for men (P < 0.05). Both vertebral and other osteoporotic fractures, showed an increased risk of hospitalisation, HR = 1.4 (95% CI: 1.3-1.7) and 1.2 (95% CI: 1.1-1.2) respectively (P < 0.0001). Individuals with vertebral fractures had 50% (P < 0.0001) longer hospitalisation than not-fractured and 33% (P < 0.002) longer than the other osteoporotic fractures group.

Conclusion

individuals with a history of clinical vertebral fracture seem to carry the greatest health burden compared with other fracture groups, emphasising the attention which should be given to those individuals.

SUBMITTER: Siggeirsdottir K

PROVIDER: S-EPMC3335370 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Publications

Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study.

Siggeirsdottir Kristin K Aspelund Thor T Jonsson Brynjolfur Y BY Mogensen Brynjolfur B Launer Lenore J LJ Harris Tamara B TB Sigurdsson Gunnar G Gudnason Vilmundur V

Age and ageing 20120223 3

<h4>Background</h4>understanding the determinants of health burden after a fracture in ageing populations is important.<h4>Objective</h4>assess the effect of clinical vertebral and other osteoporotic fractures on function and the subsequent risk of hospitalisation.<h4>Design</h4>individuals from the prospective population-based cohort study Age, Gene/Environment Susceptibility (AGES)-Reykjavik study were examined between 2002 and 2006 and followed up for 5.4 years.<h4>Subjects</h4>a total of 5,7 ...[more]

PMID: 22367357

Similar Datasets

Project description:The evolution of pain and quality of life after a symptomatic vertebral fracture differs according to patient gender, with a worse evolution in women independently of the treatment received.PurposeIn a previous randomized clinical study comparing the effect of vertebroplasty (VP) vs. conservative therapy (CT) on pain evolution and quality of life (QoL) of patients with symptomatic vertebral fractures (VF), we observed the development of chronic back pain in 23% of subjects, independently of the therapy received. This study analyses the effect of gender on the evolution of pain and QoL in these subjects.Methods118/125 randomized patients (27 males/91 females) with recent symptomatic VFs were evaluated. All received a standardized analgesic and antiosteoporotic format of treatment. Pain and QoL were evaluated by VAS and Qualeffo-41, respectively, at baseline, at 2 weeks and 2 and 6 months. We compared pain evolution and QoL after treatment (CT vs. VP) according to gender, and analysed factors including age, time of evolution, treatment received, baseline VAS, previous VFs (total and recent), incidental VFs, lumbar and femoral T-scores, and analgesic and antiosteoporotic treatment.ResultsAt baseline, there were no differences in age (males 74.8 ± 11.2 vs. females:73.2 ± 8.7 years), time of evolution, number of VFs (males:3.8 ± 2.4 vs. females: 3.1 ± 2.4), treatment received (VP, males:59%, females:45%), lumbar or femoral T-score, baseline VAS (males:6.8 ± 2.1 vs. females:6.8 ± 2.2) or Qualeffo score (males:52.2 ± 24.4 vs. females:59.7 ± 20.6). Pain and QoL evolution differed according to gender, being better in males. These differences were significant after two months independently of the treatment and the development of incidental VF during follow-up.ConclusionsPain and QoL evolution after a symptomatic VF differs according to gender, with a worse evolution in women independently of the treatment received.

Dataset Information

Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study.

Background

Objective

Design

Subjects

Method

Results

Conclusion

Publications

Effect of vertebral fractures on function, quality of life and hospitalisation the AGES-Reykjavik study.

Similar Datasets

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