Ontology highlight
ABSTRACT:
SUBMITTER: Gandhi K
PROVIDER: S-EPMC3335679 | biostudies-literature | 2012 May
REPOSITORIES: biostudies-literature
Gandhi Kavita K Thera Mahamadou A MA Coulibaly Drissa D Traoré Karim K Guindo Ando B AB Doumbo Ogobara K OK Takala-Harrison Shannon S Plowe Christopher V CV
The American journal of tropical medicine and hygiene 20120501 5
The malaria vaccine RTS,S/AS01, based on immunogenic regions of the Plasmodium falciparum circumsporozoite protein (CSP), has partial efficacy against clinical malaria in African children. Understanding how sequence diversity in CSP T- and B-cell epitopes relates to naturally acquired and vaccine-induced immunity may be useful in efforts to improve the efficacy of CSP-based vaccines. However, limitations in sequencing technology have precluded thorough evaluation of diversity in the immunogenic ...[more]