Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.
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ABSTRACT:
SUBMITTER: Ding H
PROVIDER: S-EPMC3337217 | biostudies-literature | 2011 Oct
REPOSITORIES: biostudies-literature
Publications
Association of SNCA with Parkinson: replication in the Harvard NeuroDiscovery Center Biomarker Study.
Ding Hongliu H Sarokhan Alison K AK Roderick Sarah S SS Bakshi Rachit R Maher Nancy E NE Ashourian Paymon P Kan Caroline G CG Chang Sunny S Santarlasci Andrea A Swords Kyleen E KE Ravina Bernard M BM Hayes Michael T MT Sohur U Shivraj US Wills Anne-Marie AM Flaherty Alice W AW Unni Vivek K VK Hung Albert Y AY Selkoe Dennis J DJ Schwarzschild Michael A MA Schlossmacher Michael G MG Sudarsky Lewis R LR Growdon John H JH Ivinson Adrian J AJ Hyman Bradley T BT Scherzer Clemens R CR
Movement disorders : official journal of the Movement Disorder Society 20110923 12
<h4>Background</h4>Mutations in the α-synuclein gene (SNCA) cause autosomal dominant forms of Parkinson's disease, but the substantial risk conferred by this locus to the common sporadic disease has only recently emerged from genome-wide association studies.<h4>Methods</h4>We genotyped a prioritized noncoding variant in SNCA intron 4 in 344 patients with Parkinson's disease and 275 controls from the longitudinal Harvard NeuroDiscovery Center Biomarker Study.<h4>Results</h4>The common minor allel ...[more]
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