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Recent advances in the molecular understanding of glioblastoma.

ABSTRACT: Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has been the only confirmed molecular predictive factor in glioblastoma. Novel "genome-wide" techniques have identified additional important molecular alterations as mutations in isocitrate dehydrogenase 1 (IDH1) and its prognostic importance. This review summarizes findings and techniques of genetic, epigenetic, transcriptional, and proteomic studies of glioblastoma. It provides the clinician with an up-to-date overview of current identified molecular alterations that should ultimately lead to new therapeutic targets and more individualized treatment approaches in glioblastoma.

SUBMITTER: Bleeker FE

PROVIDER: S-EPMC3337398 | biostudies-literature | 2012 May

REPOSITORIES: biostudies-literature

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Recent advances in the molecular understanding of glioblastoma.

Bleeker Fonnet E FE Molenaar Remco J RJ Leenstra Sieger S

Journal of neuro-oncology 20120120 1

Glioblastoma is the most common and most aggressive primary brain tumor. Despite maximum treatment, patients only have a median survival time of 15 months, because of the tumor's resistance to current therapeutic approaches. Thus far, methylation of the O (6)-methylguanine-DNA methyltransferase (MGMT) promoter has been the only confirmed molecular predictive factor in glioblastoma. Novel "genome-wide" techniques have identified additional important molecular alterations as mutations in isocitrat ...[more]

PMID: 22270850

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Dataset Information

Recent advances in the molecular understanding of glioblastoma.

Publications

Recent advances in the molecular understanding of glioblastoma.

Similar Datasets

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