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Glia instruct developmental neuronal remodeling through TGF-? signaling.

ABSTRACT: We found that glia secrete myoglianin, a TGF-? ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling.

SUBMITTER: Awasaki T

PROVIDER: S-EPMC3337551 | biostudies-literature | 2011 Jun

REPOSITORIES: biostudies-literature

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Glia instruct developmental neuronal remodeling through TGF-β signaling.

Awasaki Takeshi T Huang Yaling Y O'Connor Michael B MB Lee Tzumin T

Nature neuroscience 20110619 7

We found that glia secrete myoglianin, a TGF-β ligand, to instruct developmental neural remodeling in Drosophila. Glial myoglianin upregulated neuronal expression of an ecdysone nuclear receptor that triggered neurite remodeling following the late-larval ecdysone peak. Thus glia orchestrate developmental neural remodeling not only by engulfment of unwanted neurites but also by enabling neuron remodeling. ...[more]

PMID: 21685919

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